Two RFLPs for human α-2 macroglobulin (A2M)

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منابع مشابه

A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene.

Description: Alpha-2-macroglobulin is a major proteinase inhibitor in man. To study the bait domain, which defines the inhibitory spectrum of the protein and which is encoded by two exons (1), primers were designed to amplify the second exon.

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Intradiscal Injection of an Autologous Alpha-2-Macroglobulin (A2M) Concentrate Alleviates Back Pain in FAC-Positive Patients

Objectives: A cartilage degradation product, the Fibronectin-Aggrecan complex (FAC), has been identified in patients with degenerative disc disease (DDD). Alpha-2-macroglobulin (A2M) can prevent the formation of the G3 domain of aggrecan, reducing the fibronectin-aggrecan G3 complex and therefore may be an efficacious treatment. The present study was designed to determine a. The ability of auto...

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High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head

  Background: Diagnosis of osteonecrosis of the femoral head (ONFH) is complicated due to the lack of reliable serum biomarkers. Up-regulation of alpha-2-macroglobulin (A2M) gene has been reported in glucocorticoid-induced ANFH rat model. This study aimed to investigate whether the serum level of alpha-2-macroglobulin (A2M) can be used for ONFH diagnosis. Methods: Serum protein capillary elect...

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Two RFLPs at the TNP1 locus.

Source/Description: The Human Transition Protein 1 gene (TNP1) probe (1) used was a 700 bp genomic DNA sequence cloned into the Smal site of pUC8 and was supplied by W.Engel. Polymorphisms: TNP1 identifies a two allele polymorphism with TaqI: Al = 9.6 kb; A2 = 8.4 kb. Frequency: Analysis of 20 unrelated individuals yielded frequencies: Al = 0.23; A2 = 0.77. Rsal in a screen of 10-20 unrelated i...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 1985

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/13.18.6787